Ao L, Noordam R, Rensen PCN, van Heemst D, Willems van Dijk K. The role of genetically-influenced phospholipid transfer protein activity in lipoprotein metabolism and coronary artery disease. J Clin Lipidol. 2024;18(4):e579-e87.
Cofiño-Fabres C, Boonen T, Rivera-Arbeláez JM, Rijpkema M, Blauw L, Rensen PCN, et al.
Micro-Engineered Heart Tissues On-Chip with Heterotypic Cell Composition Display Self-Organization and Improved Cardiac Function. Adv Healthc Mater. 2024;13(18):e2303664.
Cypess AM, Cannon B, Nedergaard J, Kazak L, Chang DC, Krakoff J, et al.
Emerging debates and resolutions in brown adipose tissue research. Cell Metab. 2024.
Deng H, Liang WY, Chen LQ, Yuen TH, Sahin B, Vasilescu DM, et al.
CETP inhibition enhances monocyte activation and bacterial clearance and reduces streptococcus pneumonia-associated mortality in mice. JCI Insight. 2024;9(8).
Di X, Martinez-Tellez B, Krekels EHJ, Jurado-Fasoli L, Osuna-Prieto FJ, Ortiz-Alvarez L, et al.
Higher Plasma Levels of Endocannabinoids and Analogues Correlate With a Worse Cardiometabolic Profile in Young Adults. J Clin Endocrinol Metab. 2024;109(5):1351-60.
Ge X, Slütter B, Lambooij JM, Zhou E, Ying Z, Agirman C, et al.
DHCR24 inhibitor SH42 increases desmosterol without preventing atherosclerosis development in mice. iScience. 2024;27(6):109830.
Gregersen I, Kong XY, Kooijman S, Foyn H, Grannes H, Olsen MB, et al.
T cells with increased responsiveness cause obesity in mice without diet intervention. iScience. 2024;27(4):109471.
He M, Hou G, Liu M, Peng Z, Guo H, Wang Y, et al.
Lipidomic studies revealing serological markers associated with the occurrence of retinopathy in type 2 diabetes. J Transl Med. 2024;22(1):448.
Hoekx CA, Martinez-Tellez B, Straat ME, Bizino MB, van Eyk HJ, Lamb HJ, et al.
Circulating FGF21 is lower in South Asians compared to Europids with type 2 diabetes mellitus. Endocr Connect. 2024.
Hoekx CA, Martinez-Tellez B, Straat ME, Verkleij MMA, Kemmeren M, Kooijman S, et al.
Cold exposure increases circulating fibroblast growth factor 21 in the evening in males and females. Endocr Connect. 2024;13(7).
Kovynev A, Ying Z, Zhang S, Olgiati E, Lambooij JM, Visentin C, et al.
Timing Matters: Late, but Not Early, Exercise Training Ameliorates MASLD in Part by Modulating the Gut-Liver Axis in Mice. J Pineal Res. 2024;76(8):e70003.
Li M, Barros-Pinkelnig M, Weiss G, Rensen PCN, Kooijman S. Brown adipose tissue facilitates the fever response following infection with Salmonella enterica serovar Typhimurium in mice. J Lipid Res. 2024;65(9):100617.
Li M, Noordam R, Trompet S, Winter EM, Jukema JW, Arbous MS, et al.
The impact of statin use on sepsis mortality. J Clin Lipidol. 2024.
Li M, Noordam R, Winter EM, van Meurs M, Bouma HR, Arbous MS, et al.
Hydrocortisone-associated death and hospital length of stay in patients with sepsis: A retrospective cohort of large-scale clinical care data. Biomed Pharmacother. 2024;170:115961.
Li S, Zhang S, Rensen PCN, Meijer OC, Kooijman S, Kroon J. Out-of-phase treatment with the synthetic glucocorticoid betamethasone disturbs glucose metabolism in mice. Life Sci. 2024;357:123080.
Modder M, Coomans CP, Saaltink DJ, Tersteeg MMH, Hoogduin J, Scholten L, et al.
Doublecortin-like knockdown in mice attenuates obesity by stimulating energy expenditure in adipose tissue. Sci Rep. 2024;14(1):19517.
Modder M, Het Panhuis WI, Li M, Afkir S, Dorn AL, Pronk ACM, et al.
Liver-targeted Angptl4 silencing by antisense oligonucleotide treatment attenuates hyperlipidemia and atherosclerosis development in APOE*3-Leiden.CETP mice. Cardiovasc Res. 2024.
Regmi A, Aihara E, Christe ME, Varga G, Beyer TP, Ruan X, et al.
Tirzepatide modulates the regulation of adipocyte nutrient metabolism through long-acting activation of the GIP receptor. Cell Metab. 2024;36(8):1898-9.
Regmi A, Aihara E, Christe ME, Varga G, Beyer TP, Ruan X, et al.
Tirzepatide modulates the regulation of adipocyte nutrient metabolism through long-acting activation of the GIP receptor. Cell Metab. 2024;36(7):1534-49.e7.
Sass F, Ma T, Ekberg JH, Kirigiti M, Ureña MG, Dollet L, et al.
NK2R control of energy expenditure and feeding to treat metabolic diseases. Nature. 2024;635(8040):987-1000.
Schaftenaar FH, van Dam AD, de Bruin G, Depuydt MAC, de Mol J, Amersfoort J, et al.
Immunoproteasomal Inhibition With ONX-0914 Attenuates Atherosclerosis and Reduces White Adipose Tissue Mass and Metabolic Syndrome in Mice. Arterioscler Thromb Vasc Biol. 2024;44(6):1346-64.
Schönke M, Rensen PCN. Mouse Models for the Study of Liver Fibrosis Regression In Vivo and Ex Vivo. J Clin Transl Hepatol. 2024;12(11):930-8.
van der Vaart JI, van Eenige R, Rensen PCN, Kooijman S. Atherosclerosis: an overview of mouse models and a detailed methodology to quantify lesions in the aortic root. Vasc Biol. 2024;6(1).
van der Velden AIM, Koudijs A, Kooijman S, Rietjens RGJ, Sol W, Avramut MC, et al.
Fasting mimicking diet in diabetic mice partially preserves glomerular endothelial glycocalyx coverage, without changing the diabetic metabolic environment. Am J Physiol Renal Physiol. 2024;326(5):F681-f93.
Yuan L, Verhoeven A, Blomberg N, van Eyk HJ, Bizino MB, Rensen PCN, et al.
Ethnic Disparities in Lipid Metabolism and Clinical Outcomes between Dutch South Asians and Dutch White Caucasians with Type 2 Diabetes Mellitus. Metabolites. 2024;14(1).
Deprince A, Hennuyer N, Kooijman S, Pronk ACM, Baugé E, Lienard V, et al
. Apolipoprotein F is reduced in humans with steatosis and controls plasma triglyceride-rich lipoprotein metabolism. Hepatology. 2023;77(4):1287-302.
Di X, Martinez-Tellez B, Krekels EHJ, Jurado-Fasoli L, Osuna-Prieto FJ, Ortiz-Alvarez L, et al.
Higher plasma levels of endocannabinoids and analogues correlate with a worse cardiometabolic profile in young adults. J Clin Endocrinol Metab. 2023.
Engelen SE, Ververs FA, Markovska A, Lagerholm BC, Kraaijenhof JM, Yousif LI, et al.
Lipoproteins act as vehicles for lipid antigen delivery and activation of invariant natural killer T cells. JCI Insight. 2023;8(9).
In Het Panhuis W, Schönke M, Modder M, Tom HE, Lalai RA, Pronk ACM, et al
. Time-restricted feeding attenuates hypercholesterolaemia and atherosclerosis development during circadian disturbance in APOE∗3-Leiden.CETP mice. EBioMedicine. 2023;93:104680.
In Het Panhuis W, Schonke M, Siebeler R, Banen D, Pronk ACM, Streefland TCM, et al
.
Circadian disruption impairs glucose homeostasis in male but not in female mice and is dependent on gonadal sex hormones. FASEB J. 2023;37(2):e22772.
Jurado-Fasoli L, Osuna-Prieto FJ, Yang W, Kohler I, Di X, Rensen PCN, et al
. High omega-6/omega-3 fatty acid and oxylipin ratio in plasma is linked to an adverse cardiometabolic profile in middle-aged adults. J Nutr Biochem. 2023;117:109331.
Kovynev A, Ying Z, Lambooij JM, van der Zande HJP, Guigas B, Rensen PCN, et al
. Early but Not Late Exercise Training in Mice Exacerbates Hepatic Inflammation in Developing Nonalcoholic Fatty Liver Disease. J Clin Transl Hepatol. 2023;11(5):1282-5.
Li S, Ying Z, Gentenaar M, Rensen PCN, Kooijman S, Visser JA, et al.
Glucocorticoid Receptor Antagonism Improves Glucose Metabolism in a Mouse Model of Polycystic Ovary Syndrome. J Endocr Soc. 2023;8(1):bvad162.
Li Z, Zhou E, Liu C, Wicks H, Yildiz S, Razack F, et al
. Dietary butyrate ameliorates metabolic health associated with selective proliferation of gut Lachnospiraceae bacterium 28-4. JCI Insight. 2023;8(4).
Liu C, Schönke M, Spoorenberg B, Lambooij JM, van der Zande HJP, Zhou E, et al
. FGF21 protects against hepatic lipotoxicity and macrophage activation to attenuate fibrogenesis in nonalcoholic steatohepatitis. Elife. 2023;12.
Liu C, Song Z, Li Z, Boon MR, Schönke M, Rensen PCN, et al
. Dietary choline increases brown adipose tissue activation markers and improves cholesterol metabolism in female APOE*3-Leiden.CETP mice. Int J Obes (Lond). 2023;47(3):236-43.
Mehta N, Dangas K, Ditmarsch M, Rensen PCN, Dicklin MR, Kastelein JJP. The evolving role of cholesteryl ester transfer protein inhibition beyond cardiovascular disease. Pharmacol Res. 2023;197:106972.
Ortiz-Alvarez L, Acosta FM, Xu H, Sanchez-Delgado G, Vilchez-Vargas R, Link A, et al
. Fecal microbiota composition is related to brown adipose tissue (18)F-fluorodeoxyglucose uptake in young adults. J Endocrinol Invest. 2023;46(3):567-76.
Osuna-Prieto FJ, Jurado-Fasoli L, Plaza-Florido A, Yang W, Kohler I, Di X, et al
. A bout of endurance and resistance exercise transiently decreases plasma levels of bile acids in young, sedentary adults. Scand J Med Sci Sports. 2023;33(9):1607-20.
Osuna-Prieto FJ, Xu H, Ortiz-Alvarez L, Di X, Kohler I, Jurado-Fasoli L, et al
. The relative abundance of fecal bacterial species belonging to the Firmicutes and Bacteroidetes phyla is related to plasma levels of bile acids in young adults. Metabolomics. 2023;19(6):54.
Reiche ME, Poels K, Bosmans LA, Vos WG, Van Tiel CM, Gijbels MJJ, et al
. Adipocytes control hematopoiesis and inflammation through CD40 signaling. Haematologica. 2023;108(7):1873-85.
Rietjens RGJ, Wang G, van der Velden AIM, Koudijs A, Avramut MC, Kooijman S, et al
. Phosphatidylinositol metabolism of the renal proximal tubule S3 segment is disturbed in response to diabetes. Sci Rep. 2023;13(1):6261.
Sardjoe Mishre ASD, Martinez-Tellez B, Straat ME, Boon MR, Dzyubachyk O, Webb AG, et al
. Image registration and mutual thresholding enable low interimage variability across dynamic MRI measurements of supraclavicular brown adipose tissue during mild cold exposure. Magn Reson Med. 2023;90(4):1316-27.
Schönke M, Ying Z, Kovynev A, In Het Panhuis W, Binnendijk A, van der Poel S, et al
. Time to run: Late rather than early exercise training in mice remodels the gut microbiome and reduces atherosclerosis development. Faseb j. 2023;37(1):e22719.
Straat ME, Hoekx CA, van Velden FHP, Pereira Arias-Bouda LM, Dumont L, Blondin DP, et al
. Stimulation of the beta-2-adrenergic receptor with salbutamol activates human brown adipose tissue. Cell Rep Med. 2023;4(2):100942.
Straat ME, Martinez-Tellez B, van Eyk HJ, Bizino MB, van Veen S, Vianello E, et al
. Differences in Inflammatory Pathways Between Dutch South Asians vs Dutch Europids With Type 2 Diabetes. J Clin Endocrinol Metab. 2023;108(4):931-40.
van Eenige R, Ying Z, Tramper N, Wiebing V, Siraj Z, de Boer JF, et al
. Combined glucose-dependent insulinotropic polypeptide receptor and glucagon-like peptide-1 receptor agonism attenuates atherosclerosis severity in APOE*3-Leiden.CETP mice. Atherosclerosis. 2023;372:19-31.
Vos DY, Wijers M, Smit M, Huijkman N, Kloosterhuis NJ, Wolters JC, et al
. Cargo-Specific Role for Retriever Subunit VPS26C in Hepatocyte Lipoprotein Receptor Recycling to Control Postprandial Triglyceride-Rich Lipoproteins. Arterioscler Thromb Vasc Biol. 2023;43(1):e29-e45.
Ying Z, Tramper N, Zhou E, Boon MR, Rensen PCN, Kooijman S. Role of thermogenic adipose tissue in lipid metabolism and atherosclerotic cardiovascular disease: lessons from studies in mice and humans. Cardiovasc Res. 2023;119(4):905-18.
Ying Z, van Eenige R, Beerepoot R, Boon MR, Kloosterhuis NJ, van de Sluis B, et al
. Mirabegron-induced brown fat activation does not exacerbate atherosclerosis in mice with a functional hepatic ApoE-LDLR pathway. Pharmacol Res. 2023;187:106634.
Ying Z, van Eenige R, Ge X, van Marwijk C, Lambooij JM, Guigas B, et al
. Combined GIP receptor and GLP1 receptor agonism attenuates NAFLD in male APOE∗3-Leiden.CETP mice. EBioMedicine. 2023;93:104684.
Yuan L, Li-Gao R, Verhoeven A, van Eyk HJ, Bizino MB, Rensen PCN, et al
. Altered high-density lipoprotein composition is associated with risk for complications in type 2 diabetes mellitus in South Asian descendants: A cross-sectional, case-control study on lipoprotein subclass profiling. Diabetes Obes Metab. 2023;25(8):2374-87.
Yue K, Rensen PC, Kooijman S. Circadian control of white and brown adipose tissues. Curr Opin Genet Dev. 2023;80:102056.
Zhou E, Ge X, Nakashima H, Li R, van der Zande HJP, Liu C, et al
. Inhibition of DHCR24 activates LXRα to ameliorate hepatic steatosis and inflammation. EMBO Mol Med. 2023;15(8):e16845.
Borup A, Donkin I, Boon MR, Frydland M, Martinez-Tellez B, Loft A, et al
.
Association of apolipoprotein M and sphingosine-1-phosphate with brown adipose tissue after cold exposure in humans. Sci Rep. 2022;12(1):18753.
Burggraaf B, Pouw NMC, Fernández Arroyo S, van Vark-van der Zee LC, van de Geijn GM, Birnie E, et al
.
Effects of dapagliflozin on postprandial lipid metabolism in type 2 diabetes mellitus. Eur J Endocrinol. 2022;186(5):597-605.
Deprince A, Hennuyer N, Kooijman S, Pronk ACM, Bauge E, Lienard V, et al
.
Apolipoprotein F is reduced in humans with steatosis and controls plasma triglyceride-rich lipoprotein metabolism. Hepatology. 2022.
Dijk W, Di Filippo M, Kooijman S, van Eenige R, Rimbert A, Caillaud A, et al
.
Identification of a Gain-of-Function LIPC Variant as a Novel Cause of Familial Combined Hypocholesterolemia. Circulation. 2022;146(10):724-39.
He M, Wang J, Liang Q, Li M, Guo H, Wang Y, et al
.
Time-restricted eating with or without low-carbohydrate diet reduces visceral fat and improves metabolic syndrome: A randomized trial. Cell Rep Med. 2022;3(10):100777.
Ibi D, Boot M, Dollé MET, Jukema JW, Rosendaal FR, Christodoulides C, et al
.
Apolipoprotein A-V is a potential target for treating coronary artery disease: evidence from genetic and metabolomic analyses. J Lipid Res. 2022;63(5):100193.
In Het Panhuis W, Schonke M, Siebeler R, Afkir S, Baelde R, Pronk ACM, et al
.
Aging attenuates diurnal lipid uptake by brown adipose tissue. Aging (Albany NY). 2022;14(19):7734-51.
In het Panhuis W, Tsaalbi-Shtylik A, Schönke M, van Harmelen V, Pronk ACM, Streefland TCM, et al
.
Rev1 deficiency induces replication stress to cause metabolic dysfunction differently in males and females. Am J Physiol Endocrinol Metab. 2022;322(3):E319-e29.
Jurado-Fasoli L, Di X, Kohler I, Osuna-Prieto FJ, Hankemeier T, Krekels E, et al
.
Omega-6 and omega-3 oxylipins as potential markers of cardiometabolic risk in young adults. Obesity (Silver Spring). 2022;30(1):50-61.
Jurado-Fasoli L, Di X, Sanchez-Delgado G, Yang W, Osuna-Prieto FJ, Ortiz-Alvarez L, et al
.
Acute and long-term exercise differently modulate plasma levels of oxylipins, endocannabinoids, and their analogues in young sedentary adults: A sub-study and secondary analyses from the ACTIBATE randomized controlled-trial. EBioMedicine. 2022;85:104313.
Katiraei S, van Diepen JA, Tavares LP, Hoving LR, Pronk A, Verschueren I, et al
.
Bone marrow transplantation induces changes in the gut microbiota that chronically increase the cytokine response pattern of splenocytes. Sci Rep. 2022;12(1):6883.
Koorneef LL, van der Meulen M, Kooijman S, Sanchez-Lopez E, Scheerstra JF, Voorhoeve MC, et al
.
Dexamethasone-associated metabolic effects in male mice are partially caused by depletion of endogenous corticosterone. Front Endocrinol (Lausanne). 2022;13:960279.
Liu C, Li Z, Song Z, Fan X, Shao H, Schonke M, et al
.
Choline and butyrate beneficially modulate the gut microbiome without affecting atherosclerosis in APOE*3-Leiden.CETP mice. Atherosclerosis. 2022;362:47-55.
Liu C, Schönke M, Zhou E, Li Z, Kooijman S, Boon MR, et al
.
Pharmacological treatment with FGF21 strongly improves plasma cholesterol metabolism to reduce atherosclerosis. Cardiovasc Res. 2022;118(2):489-502.
Madrigal-Matute J, de Bruijn J, van Kuijk K, Riascos-Bernal DF, Diaz A, Tasset I, et al
.
Protective role of chaperone-mediated autophagy against atherosclerosis. Proc Natl Acad Sci U S A. 2022;119(14):e2121133119.
Martinez-Tellez B, Sanchez-Delgado G, Acosta FM, Alcantara JMA, Amaro-Gahete FJ, Martinez-Avila WD, et al
.
No evidence of brown adipose tissue activation after 24 weeks of supervised exercise training in young sedentary adults in the ACTIBATE randomized controlled trial. Nat Commun. 2022;13(1):5259.
Ortiz-Alvarez L, Acosta FM, Xu H, Sanchez-Delgado G, Vilchez-Vargas R, Link A, et al
.
Fecal microbiota composition is related to brown adipose tissue (18)F-fluorodeoxyglucose uptake in young adults. J Endocrinol Invest. 2022.
Ortiz-Alvarez L, Xu H, Di X, Kohler I, Osuna-Prieto FJ, Acosta FM, et al
.
Plasma Levels of Endocannabinoids and Their Analogues Are Related to Specific Fecal Bacterial Genera in Young Adults: Role in Gut Barrier Integrity. Nutrients. 2022;14(10).
Osuna-Prieto FJ, Rubio-Lopez J, Di X, Yang W, Kohler I, Rensen PCN, et al
.
Plasma Levels of Bile Acids Are Related to Cardiometabolic Risk Factors in Young Adults. J Clin Endocrinol Metab. 2022;107(3):715-23.
Paalvast Y, Zhou E, Rozendaal YJW, Wang Y, Gerding A, van Dijk TH, et al
.
A Systems Analysis of Phenotype Heterogeneity in APOE*3Leiden.CETP Mice Induced by Long-Term High-Fat High-Cholesterol Diet Feeding. Nutrients. 2022;14(22).
Reiche ME, Poels K, Bosmans LA, Vos WG, Van Tiel CM, Gijbels MJJ, et al
.
Adipocytes control haematopoiesis and inflammation through CD40 signaling. Haematologica. 2022.
Rimbert A, Yeung MW, Dalila N, Thio CHL, Yu H, Loaiza N, et al
.
Variants in the GPR146 Gene Are Associated With a Favorable Cardiometabolic Risk Profile. Arterioscler Thromb Vasc Biol. 2022;42(10):1262-71.
Rios-Morales M, Vieira-Lara MA, Homan E, Langelaar-Makkinje M, Gerding A, Li Z, et al
.
Butyrate oxidation attenuates the butyrate-induced improvement of insulin sensitivity in myotubes. Biochim Biophys Acta Mol Basis Dis. 2022;1868(11):166476.
Sardjoe Mishre ASD, Martinez-Tellez B, Acosta FM, Sanchez-Delgado G, Straat ME, Webb AG, et al
.
Association of shivering threshold time with body composition and brown adipose tissue in young adults. J Therm Biol. 2022;108:103277.
Sardjoe Mishre ASD, Straat ME, Martinez-Tellez B, Mendez Gutierrez A, Kooijman S, Boon MR, et al
.
The Infrared Thermography Toolbox: An Open-access Semi-automated Segmentation Tool for Extracting Skin Temperatures in the Thoracic Region including Supraclavicular Brown Adipose Tissue. J Med Syst. 2022;46(12):89.
Straat ME, Jurado-Fasoli L, Ying Z, Nahon KJ, Janssen LGM, Boon MR, et al
.
Cold exposure induces dynamic changes in circulating triacylglycerol species, which is dependent on intracellular lipolysis: A randomized cross-over trial. EBioMedicine. 2022;86:104349.
Straat ME, Martinez-Tellez B, Janssen LGM, van Veen S, van Eenige R, Kharagjitsing AV, et al
.
The effect of cold exposure on circulating transcript levels of immune genes in Dutch South Asian and Dutch Europid men. J Therm Biol. 2022;107:103259.
Straat ME, Martinez-Tellez B, Nahon KJ, Janssen LGM, Verhoeven A, van der Zee L, et al
.
Comprehensive (apo)lipoprotein profiling in patients with genetic hypertriglyceridemia using LC-MS and NMR spectroscopy. J Clin Lipidol. 2022;16(4):472-82.
Straat ME, Martinez-Tellez B, Sardjoe Mishre A, Verkleij MMA, Kemmeren M, Pelsma ICM, et al
.
Cold-induced thermogenesis shows a diurnal variation, that unfolds differently in males and females. J Clin Endocrinol Metab. 2022.
Straat ME, Martinez-Tellez B, van Eyk HJ, Bizino MB, van Veen S, Vianello E, et al
.
Differences in inflammatory pathways between Dutch South Asians versus Dutch Europids with type 2 diabetes. J Clin Endocrinol Metab. 2022.
Svedlund Eriksson E, Johansson I, Martensson AKF, Lantero Rodriguez M, Schilperoort M, Kroon J, et al
.
Castration of Male Mice Induces Metabolic Remodeling of the Heart. J Endocr Soc. 2022;6(11):bvac132.
van Eenige R & In Het Panhuis W, Schönke M, Jouffe C, Devilee TH, Siebeler R, et al
.
Angiopoietin-like 4 governs diurnal lipoprotein lipase activity in brown adipose tissue. Mol Metab. 2022;60:101497.
Xu H, Jurado-Fasoli L, Ortiz-Alvarez L, Osuna-Prieto FJ, Kohler I, Di X, et al
.
Plasma Levels of Omega-3 and Omega-6 Derived Oxylipins Are Associated with Fecal Microbiota Composition in Young Adults. Nutrients. 2022;14(23).
Ying Z, Tramper N, Zhou E, Boon MR, Rensen PCN, Kooijman S. Role of thermogenic adipose tissue in lipid metabolism and atherosclerotic cardiovascular disease: lessons from studies in mice and humans. Cardiovasc Res. 2022.
Bizino MB, Jazet IM, van Eyk HJ, Rensen PCN, Geelhoed-Duijvestijn PH, Kharagjitsingh AV, et al. Efficacy of liraglutide on glycemic endpoints in people of Western European and South Asian descent with T2DM using multiple daily insulin injections: results of the MAGNA VICTORIA studies. Acta Diabetol. 2021.
Blauw LL, Noordam R, van der Laan SW, Trompet S, Kooijman S, van Heemst D, et al
.
Common Genetic Variation in MC4R Does Not Affect Atherosclerotic Plaque Phenotypes and Cardiovascular Disease Outcomes. J Clin Med. 2021;10(5).
Bos MM, de Vries L, Rensen PC, Willems van Dijk K, Blauw GJ, van Heemst D, et al
.
Apolipoprotein E genotype, lifestyle and coronary artery disease: Gene-environment interaction analyses in the UK Biobank population. Atherosclerosis. 2021;328:33-7.
Bos MM, Goulding NJ, Lee MA, Hofman A, Bot M, Pool R, et al. Investigating the relationships between unfavourable habitual sleep and metabolomic traits: evidence from multi-cohort multivariable regression and Mendelian randomization analyses. BMC Med. 2021;19(1):69.
Brunham LR, Trinder M, Rensen PCN, Boyd J. Response by Brunham et al
to Letter Regarding Article, "Inhibition of Cholesteryl Ester Transfer Protein Preserves High-Density Lipoprotein Cholesterol and Improves Survival in Sepsis". Circulation. 2021;144(6):e122.
Clemente-Olivo MP, Habibe JJ, Vos M, Ottenhoff R, Jongejan A, Herrema H, et al
.
Four-and-a-half LIM domain protein 2 (FHL2) deficiency protects mice from diet-induced obesity and high FHL2 expression marks human obesity. Metabolism. 2021;121:154815.
Florijn BW, Duijs J, Klaver M, Kuipers EN, Kooijman S, Prins J, et al
.
Estradiol-driven metabolism in transwomen associates with reduced circulating extracellular vesicle microRNA-224/452. Eur J Endocrinol. 2021;185(4):539-52.
Hoekstra M, Ren B, Laurila PP, Hildebrand RB, Soronen J, Frodermann V, et al
.
Hematopoietic upstream stimulating factor 1 deficiency is associated with increased atherosclerosis susceptibility in LDL receptor knockout mice. Sci Rep. 2021;11(1):16419.
Hoogerland JA, Peeks F, Hijmans BS, Wolters JC, Kooijman S, Bos T, et al. Impaired VLDL catabolism links hypoglycemia to hypertriglyceridemia in GSD Ia. J Inherit Metab Dis. 2021.
Hoogerland JA, Peeks F, Hijmans BS, Wolters JC, Kooijman S, Bos T, et al
.
Impaired Very-Low-Density Lipoprotein catabolism links hypoglycemia to hypertriglyceridemia in Glycogen Storage Disease type Ia. J Inherit Metab Dis. 2021;44(4):879-92.
Ibi D, Blauw LL, Noordam R, Dollé MET, Jukema JW, Rosendaal FR, et al
.
Triglyceride-lowering LPL alleles combined with LDL-C-lowering alleles are associated with an additively improved lipoprotein profile. Atherosclerosis. 2021;328:144-52.
Jurado-Fasoli L, Di X, Kohler I, Osuna-Prieto FJ, Hankemeier T, Krekels E, et al
.
Omega-6 and omega-3 oxylipins as potential markers of cardiometabolic risk in young adults. Obesity
(Silver Spring). 2021.
Kroon J, Schilperoort M, In Het Panhuis W, van den Berg R, van Doeselaar L, Verzijl CRC, et al.
A physiological glucocorticoid rhythm is an important regulator of brown adipose tissue function. Mol Metab. 2021;47:101179.
Kroon J, Viho EMG, Gentenaar M, Koorneef LL, van Kooten C, Rensen PCN, et al
.
The development of novel glucocorticoid receptor antagonists: From rational chemical design to therapeutic efficacy in metabolic disease models. Pharmacol Res. 2021;168:105588.
Lantero Rodriguez M, Schilperoort M, Johansson I, Svedlund Eriksson E, Palsdottir V, Kroon J, et al
.
Testosterone reduces metabolic brown fat activity in male mice. J Endocrinol. 2021.
Liu C, Schonke M, Zhou E, Li Z, Kooijman S, Boon MR, et al. Pharmacological treatment with FGF21 strongly improves plasma cholesterol metabolism to reduce atherosclerosis. Cardiovasc Res. 2021.
Osuna-Prieto FJ, Martinez-Tellez B, Ortiz-Alvarez L, Di X, Jurado-Fasoli L, Xu H, et al
.
Elevated plasma succinate levels are linked to higher cardiovascular disease risk factors in young adults. Cardiovasc Diabetol. 2021;20(1):151.
Osuna-Prieto FJ, Rubio-Lopez J, Di X, Yang W, Kohler I, Rensen PCN, et al
.
Plasma levels of bile acids are related to cardiometabolic risk factors in young adults. J Clin Endocrinol Metab. 2021.
Schilperoort M, Kroon J, Kooijman S, Smit AE, Gentenaar M, Mletzko K, et al
.
Loss of glucocorticoid rhythm induces an osteoporotic phenotype in female mice. Aging Cell. 2021;20(10):e13474.
Straat ME, Hogenboom R, Boon MR, Rensen PCN, Kooijman S. Circadian control of brown adipose tissue. Biochim Biophys Acta Mol Cell Biol Lipids. 2021;1866(8):158961.
Sveidahl Johansen O, Ma T, Hansen JB, Markussen LK, Schreiber R, Reverte-Salisa L, et al
.
Lipolysis drives expression of the constitutively active receptor GPR3 to induce adipose thermogenesis. Cell. 2021;184(13):3502-18.e33.
Trinder M, Wang Y, Madsen CM, Ponomarev T, Bohunek L, Daisely BA, et al. Inhibition of Cholesteryl Ester Transfer Protein Preserves High-Density Lipoprotein Cholesterol and Improves Survival in Sepsis. Circulation. 2021;143(9):921-34.
van Eenige R, Ying Z, Tambyrajah L, Pronk ACM, Blomberg N, Giera M, et al. Cannabinoid type 1 receptor inverse agonism attenuates dyslipidemia and atherosclerosis in APOE*3-Leiden.CETP mice. J Lipid Res. 2021.
Wang XL, Kooijman S, Gao Y, Tzeplaeff L, Cosquer B, Milanova I, et al
.
Microglia-specific knock-down of Bmal1 improves memory and protects mice from high fat diet-induced obesity. Mol Psychiatry. 2021.
Ying Z, Boon MR, Coskun T, Kooijman S, Rensen PCN. A simplified procedure to trace triglyceride-rich lipoprotein metabolism in vivo. Physiol Rep. 2021;9(8):e14820.
Winter EM, Kooijman S, Appelman-Dijkstra NM, Meijer OC, Rensen PC, Schilperoort M. Chronobiology and Chronotherapy of Osteoporosis. JBMR Plus. 2021;5(10):e10504.
Zhang X, Paalvast Y, Wang Y, Rensen PCN, Groen AK. A hierarchical dynamic model used for investigating feed efficiency and its relationship with hepatic gene expression in APOE*3-Leiden.CETP mice. Physiol Rep. 2021;9(8):e14832.
Zhou E, Li Z, Nakashima H, Choukoud A, Kooijman S, Berbee JFP, et al. Beneficial effects of brown fat activation on top of PCSK9 inhibition with alirocumab on dyslipidemia and atherosclerosis development in APOE*3-Leiden.CETP mice. Pharmacol Res. 2021;167:105524.
Zhou E, Li Z, Nakashima H, Liu C, Ying Z, Foks AC, et al
.
Hepatic Scavenger Receptor Class B Type 1 Knockdown Reduces Atherosclerosis and Enhances the Antiatherosclerotic Effect of Brown Fat Activation in APOE*3-Leiden.CETP Mice. Arterioscler Thromb Vasc Biol. 2021;41(4):1474-86.
Bizino MB, Jazet IM, de Heer P, van Eyk HJ, Dekkers IA, Rensen PCN, et al. Placebo-controlled randomised trial with liraglutide on magnetic resonance endpoints in individuals with type 2 diabetes: a pre-specified secondary study on ectopic fat accumulation. Diabetologia. 2020;63(1):65-74.
Blauw LL, Rensen PCN. Role of homeostatic iron regulator protein in hepatic cholesterol metabolism: interaction between Kupffer cells and hepatocytes? Eur Heart J. 2020.
Blauw LL, Wang Y, Willems van Dijk K, Rensen PCN. A Novel Role for CETP as Immunological Gatekeeper: Raising HDL to Cure Sepsis? Trends Endocrinol Metab. 2020;31(5):334-43.
Blondin DP, Nielsen S, Kuipers EN, Severinsen MC, Jensen VH, Miard S, et al
.
Human Brown Adipocyte Thermogenesis Is Driven by beta2-AR Stimulation. Cell Metab. 2020;32(2):287-300 e7.
Burggraaf B, Pouw NMC, Arroyo SF, van Vark-van der Zee LC, van de Geijn GM, Birnie E, et al. A placebo-controlled proof-of-concept study of alirocumab on postprandial lipids and vascular elasticity in insulin-treated patients with type 2 diabetes mellitus. Diabetes Obes Metab. 2020;22(5):807-16.
Eveleens Maarse BC, Loh NY, Karpe F, Rosendaal FR, van Heemst D, Mook-Kanamori DO, et al
.
Associations between outdoor temperature and bright sunlight with metabolites in two population-based European cohorts. Nutr Metab Cardiovasc Dis. 2020;30(12):2252-61.
Genzel L, Adan R, Berns A, van den Beucken J, Blokland A, Boddeke E, et al
.
How the COVID-19 pandemic highlights the necessity of animal research. Curr Biol. 2020;30(21):4328.
Hoekstra M, van der Sluis RJ, Hildebrand RB, Lammers B, Zhao Y, Praticò D, et al. Disruption of Phospholipid Transfer Protein-Mediated High-Density Lipoprotein Maturation Reduces Scavenger Receptor BI Deficiency-Driven Atherosclerosis Susceptibility Despite Unexpected Metabolic Complications. Arterioscler Thromb Vasc Biol. 2020;40(3):611-23.
Ibi D, Noordam R, van Klinken JB, Li-Gao R, de Mutsert R, Trompet S, et al
.
Genome-Wide Association Study of the Postprandial Triglyceride Response Yields Common Genetic Variation in LIPC (Hepatic Lipase). Circ Genom Precis Med. 2020;13(4):e002693.
In het Panhuis W, Kooijman S, Brouwers B, Verhoeven A, Pronk ACM, Streefland TCM, et al
.
Mild Exercise Does Not Prevent Atherosclerosis in APOE*3-Leiden.CETP Mice or Improve Lipoprotein Profile of Men with Obesity. Obesity. 2020;n/a(n/a)2020.
Janssen LGM, Nahon KJ, Bracké KFM, van den Broek D, Smit R, Sardjoe Mishre ASD, et al. Twelve weeks of exenatide treatment increases [(18)F]fluorodeoxyglucose uptake by brown adipose tissue without affecting oxidative resting energy expenditure in nondiabetic males. Metabolism. 2020;106:154167.
Janssen LGM, Van Dam AD, Hanssen MJW, Kooijman S, Nahon KJ, Reinders H, et al. Higher Plasma Sclerostin and Lower Wnt Signaling Gene Expression in White Adipose Tissue of Prediabetic South Asian Men Compared with White Caucasian Men. Diabetes Metab J. 2020;44(2):326-35.
Katiraei S, de Vries MR, Costain AH, Thiem K, Hoving LR, van Diepen JA, et al
.
Akkermansia muciniphila Exerts Lipid-Lowering and Immunomodulatory Effects without Affecting Neointima Formation in Hyperlipidemic APOE*3-Leiden.CETP Mice. Mol Nutr Food Res. 2020;64(15):e1900732.
Li Z, de Jonge WJ, Wang Y, Rensen PCN, Kooijman S. Electrical Neurostimulation Promotes Brown Adipose Tissue Thermogenesis. Front Endocrinol (Lausanne). 2020;11:567545.
Martinez-Tellez B, Sanchez-Delgado G, Boon MR, Rensen PCN, Llamas-Elvira JM, Ruiz JR. Distribution of Brown Adipose Tissue Radiodensity in Young Adults: Implications for Cold [(18)F]FDG-PET/CT Analyses. Mol Imaging Biol. 2020;22(2):425-33.
Nahon KJ, Janssen LGM, Sardjoe Mishre ASD, Bilsen MP, van der Eijk JA, Botani K, et al
.
The effect of mirabegron on energy expenditure and brown adipose tissue in healthy lean South Asian and Europid men. Diabetes Obes Metab. 2020;22(11):2032-44.
Paiman EHM, van Eyk HJ, van Aalst MMA, Bizino MB, van der Geest RJ, Westenberg JJM, et al. Effect of Liraglutide on Cardiovascular Function and Myocardial Tissue Characteristics in Type 2 Diabetes Patients of South Asian Descent Living in the Netherlands: A Double-Blind, Randomized, Placebo-Controlled Trial. J Magn Reson Imaging. 2020;51(6):1679-88.
Schilperoort M, Bravenboer N, Lim J, Mletzko K, Busse B, van Ruijven L, et al. Circadian disruption by shifting the light-dark cycle negatively affects bone health in mice. Faseb J. 2020;34(1):1052-64.
Schilperoort M, Rensen PCN, Kooijman S. Time for Novel Strategies to Mitigate Cardiometabolic Risk in Shift Workers. Trends Endocrinol Metab. 2020;31(12):952-64.
Schilperoort M, van den Berg R, Bosmans LA, van Os BW, Dollé MET, Smits NAM, et al. Disruption of circadian rhythm by alternating light-dark cycles aggravates atherosclerosis development in APOE*3-Leiden.CETP mice. J Pineal Res. 2020;68(1):e12614.
Schilperoort M, van den Berg R, Coomans CP, Khedoe P, Ramkisoensing A, Boekestijn S, et al
.
Continuous Light Does Not Affect Atherosclerosis in APOE*3-Leiden.CETP Mice. J Biol Rhythms. 2020;35(6):598-611.
Schönke M, Martinez-Tellez B, Rensen PCN. Role of the endocannabinoid system in the regulation of the skeletal muscle response to exercise. Curr Opin Pharmacol. 2020;52:52-602020.
Stokman G, van den Hoek AM, Denker Thorbekk D, Pieterman EJ, Skovgard Veidal S, Basta B, et al
.
Dual targeting of hepatic fibrosis and atherogenesis by icosabutate, an engineered eicosapentaenoic acid derivative. Liver Int. 2020;40(11):2860-76.
Straat ME, Schinkelshoek MS, Fronczek R, Lammers GJ, Rensen PCN, Boon MR. Role of Brown Adipose Tissue in Adiposity Associated With Narcolepsy Type 1. Front Endocrinol (Lausanne). 2020;11:145.
Thiem K, Hoeke G, Zhou E, Hijmans A, Houben T, Boels MG, et al. Deletion of haematopoietic Dectin-2 or CARD9 does not protect from atherosclerosis development under hyperglycaemic conditions. Diab Vasc Dis Res. 2020;17(1):1479164119892140.
Trinder M, Wang Y, Madsen CM, Ponomarev T, Bohunek L, Daisley BA, et al
.
Inhibition of Cholesteryl Ester Transfer Protein Preserves High-Density Lipoprotein Cholesterol and Improves Survival in Sepsis. Circulation. 2020.
van Eenige R, Verhave PS, Koemans PJ, Tiebosch I, Rensen PCN, Kooijman S. RandoMice, a novel, user-friendly randomization tool in animal research. PLoS One. 2020;15(8):e0237096.
van Eyk HJ, Paiman EHM, Bizino MB, SL IJ, Kleiburg F, Boers TGW, et al. Liraglutide decreases energy expenditure and does not affect the fat fraction of supraclavicular brown adipose tissue in patients with type 2 diabetes. Nutr Metab Cardiovasc Dis. 2020;30(4):616-24.
Wang XL, Wolff SEC, Korpel N, Milanova I, Sandu C, Rensen PCN, et al
.
Deficiency of the Circadian Clock Gene Bmal1 Reduces Microglial Immunometabolism. Front Immunol. 2020;11:586399.
Yoneshiro T, Rodriguez-Rodriguez R, Betz MJ, Rensen PCN. Editorial: Current Challenges for Targeting Brown Fat Thermogenesis to Combat Obesity. Front Endocrinol (Lausanne). 2020;11:600341.
Zhou E, Hoeke G, Li Z, Eibergen AC, Schonk AW, Koehorst M, et al
.
Colesevelam enhances the beneficial effects of brown fat activation on hyperlipidaemia and atherosclerosis development. Cardiovasc Res. 2020;116(10):1710-20.
Abreu-Vieira G, Sardjoe Mishre ASD, Burakiewicz J, Janssen LGM, Nahon KJ, van der Eijk JA, et al
.
Human Brown Adipose Tissue Estimated With Magnetic Resonance Imaging Undergoes Changes in Composition After Cold Exposure: An in vivo MRI Study in Healthy Volunteers. Front Endocrinol (Lausanne). 2019;10:898.
Acosta FM, Martinez-Tellez B, Blondin DP, Haman F, Rensen PCN, Llamas-Elvira JM, et al. Relationship between the Daily Rhythm of Distal Skin Temperature and Brown Adipose Tissue (18)F-FDG Uptake in Young Sedentary Adults. J Biol Rhythms. 2019;34(5):533-50.
Acosta FM, Sanchez-Delgado G, Martinez-Tellez B, Migueles JH, Amaro-Gahete FJ, Rensen PCN, et al. Sleep duration and quality are not associated with brown adipose tissue volume or activity-as determined by 18F-FDG uptake, in young, sedentary adults. Sleep. 2019;42(12).
Blauw LL, Noordam R, Soidinsalo S, Blauw CA, Li-Gao R, de Mutsert R, et al. Mendelian randomization reveals unexpected effects of CETP on the lipoprotein profile. Eur J Hum Genet. 2019;27(3):422-31.
Boon MR, Hanssen MJW, Brans B, Hülsman CJM, Hoeks J, Nahon KJ, et al. Effect of L-arginine on energy metabolism, skeletal muscle and brown adipose tissue in South Asian and Europid prediabetic men: a randomised double-blinded crossover study. Diabetologia. 2019;62(1):112-22.
Bos MM, Noordam R, Blauw GJ, Slagboom PE, Rensen PCN, van Heemst D. The ApoE ε4 Isoform: Can the Risk of Diseases be Reduced by Environmental Factors? J Gerontol A Biol Sci Med Sci. 2019;74(1):99-107.
Bos MM, Noordam R, van den Berg R, de Mutsert R, Rosendaal FR, Blauw GJ, et al. Associations of sleep duration and quality with serum and hepatic lipids: The Netherlands Epidemiology of Obesity Study. J Sleep Res. 2019;28(4):e12776.
Bos MM, van Heemst D, Donga E, de Mutsert R, Rosendaal FR, Blauw GJ, et al. The Association between Habitual Sleep Duration and Sleep Quality with Glycemic Traits: Assessment by Cross-Sectional and Mendelian Randomization Analyses. J Clin Med. 2019;8(5).
Christen T, Trompet S, Rensen PCN, Willems van Dijk K, Lamb HJ, Jukema JW, et al. The role of inflammation in the association between overall and visceral adiposity and subclinical atherosclerosis. Nutr Metab Cardiovasc Dis. 2019;29(7):728-35.
Donkers JM, Kooijman S, Slijepcevic D, Kunst RF, Roscam Abbing RL, Haazen L, et al. NTCP deficiency in mice protects against obesity and hepatosteatosis. JCI Insight. 2019;5(14).
Herrera Moro Chao D, Wang Y, Foppen E, Ottenhoff R, van Roomen C, Parlevliet ET, et al. The Iminosugar AMP-DNM Improves Satiety and Activates Brown Adipose Tissue Through GLP1. Diabetes. 2019;68(12):2223-34.
Janssen LGM, Jauhiainen M, Olkkonen VM, Haridas PAN, Nahon KJ, Rensen PCN, et al. Short-Term Cooling Increases Plasma ANGPTL3 and ANGPTL8 in Young Healthy Lean Men but Not in Middle-Aged Men with Overweight and Prediabetes. J Clin Med. 2019;8(8).
Katiraei S, de Vries MR, Costain AH, Thiem K, Hoving LR, van Diepen JA, et al. Akkermansia muciniphila Exerts Lipid-Lowering and Immunomodulatory Effects without Affecting Neointima Formation in Hyperlipidemic APOE*3-Leiden.CETP Mice. Mol Nutr Food Res. 2019:e1900732.
Körner A, Zhou E, Müller C, Mohammed Y, Herceg S, Bracher F, et al. Inhibition of Δ24-dehydrocholesterol reductase activates pro-resolving lipid mediator biosynthesis and inflammation resolution. Proc Natl Acad Sci U S A. 2019;116(41):20623-34.
Kuipers EN, Held NM, In Het Panhuis W, Modder M, Ruppert PMM, Kersten S, et al. A single day of high-fat diet feeding induces lipid accumulation and insulin resistance in brown adipose tissue in mice. Am J Physiol Endocrinol Metab. 2019;317(5):E820-e30.
Liu J, Kuipers EN, Sips HCM, Dorleijn JC, van Dam AD, Christodoulides C, et al. Conditionally immortalized brown preadipocytes can switch between proliferative and differentiated states. Biochim Biophys Acta Mol Cell Biol Lipids. 2019;1864(12):158511.
Martinez-Tellez B, Garcia-Rivero Y, Sanchez-Delgado G, Xu H, Amaro-Gahete FJ, Acosta FM, et al. Supraclavicular skin temperature measured by iButtons and (18)F-fluorodeoxyglucose uptake by brown adipose tissue in adults. J Therm Biol. 2019;82:178-85.
Martinez-Tellez B, Sanchez-Delgado G, Alcantara JMA, Acosta FM, Amaro-Gahete FJ, Osuna-Prieto FJ, et al. Evidence of high (18) F-fluorodeoxyglucose uptake in the subcutaneous adipose tissue of the dorsocervical area in young adults. Exp Physiol. 2019;104(2):168-73.
Nahon JE, Hoekstra M, van Harmelen V, Rensen PCN, Willems van Dijk K, Kooijman S, et al
.
Proteoglycan 4 deficiency protects against glucose intolerance and fatty liver disease in diet-induced obese mice. Biochim Biophys Acta Mol Basis Dis. 2019;1865(2):494-501.
Noordam R, Bos MM, Wang H, Winkler TW, Bentley AR, Kilpeläinen TO, et al. Multi-ancestry sleep-by-SNP interaction analysis in 126,926 individuals reveals lipid loci stratified by sleep duration. Nat Commun. 2019;10(1):5121.
Paulus A, Drude N, Nascimento EBM, Buhl EM, Berbée JFP, Rensen PCN, et al. [(18)F]BODIPY-triglyceride-containing chylomicron-like particles as an imaging agent for brown adipose tissue in vivo. Sci Rep. 2019;9(1):2706.
Ruuth M, Janssen LGM, Äikäs L, Tigistu-Sahle F, Nahon KJ, Ritvos O, et al. LDL aggregation susceptibility is higher in healthy South Asian compared with white Caucasian men. J Clin Lipidol. 2019;13(6):910-9.e2.
Schilperoort M, van den Berg R, Dollé MET, van Oostrom CTM, Wagner K, Tambyrajah LL, et al. Time-restricted feeding improves adaptation to chronically alternating light-dark cycles. Sci Rep. 2019;9(1):7874.
Thiem K, Hoeke G, van den Berg S, Hijmans A, Jacobs CWM, Zhou E, et al. Deletion of hematopoietic Dectin-2 or CARD9 does not protect against atherosclerotic plaque formation in hyperlipidemic mice. Sci Rep. 2019;9(1):4337.
Trinder M, Genga KR, Kong HJ, Blauw LL, Lo C, Li X, et al. Cholesteryl Ester Transfer Protein Influences High-Density Lipoprotein Levels and Survival in Sepsis. Am J Respir Crit Care Med. 2019;199(7):854-62.
van Eyk HJ, Blauw LL, Bizino MB, Wang Y, van Dijk KW, de Mutsert R, et al. Hepatic triglyceride content does not affect circulating CETP: lessons from a liraglutide intervention trial and a population-based cohort. Sci Rep. 2019;9(1):9996.
van Eyk HJ, Paiman EHM, Bizino MB, de Heer P, Geelhoed-Duijvestijn PH, Kharagjitsingh AV, et al. A double-blind, placebo-controlled, randomised trial to assess the effect of liraglutide on ectopic fat accumulation in South Asian type 2 diabetes patients. Cardiovasc Diabetol. 2019;18(1):87.
Vrieling F, Wilson L, Rensen PCN, Walzl G, Ottenhoff THM, Joosten SA. Oxidized low-density lipoprotein (oxLDL) supports Mycobacterium tuberculosis survival in macrophages by inducing lysosomal dysfunction. PLoS Pathog. 2019;15(4):e1007724.
Worthmann A, Schlein C, Berbée JFP, Rensen PCN, Heeren J, Bartelt A. Effects of Pharmacological Thermogenic Adipocyte Activation on Metabolism and Atherosclerotic Plaque Regression. Nutrients. 2019;11(2).
Bijkerk R, Trimpert C, van Solingen C, de Bruin RG, Florijn BW, Kooijman S, et al. MicroRNA-132 controls water homeostasis through regulating MECP2-mediated vasopressin synthesis. Am J Physiol Renal Physiol. 2018;315(4):F1129-f38.
Blauw LL, Li Z, Rensen SS, Greve JWM, Verhoeven A, Derks RJ, et al. Metabolic liver inflammation in obesity does not robustly decrease hepatic and circulating CETP. Atherosclerosis. 2018;275:149-55.
Blauw LL, Li-Gao R, Noordam R, de Mutsert R, Trompet S, Berbée JFP, et al. CETP (Cholesteryl Ester Transfer Protein) Concentration: A Genome-Wide Association Study Followed by Mendelian Randomization on Coronary Artery Disease. Circ Genom Precis Med. 2018;11(5):e002034.
Christen T, Trompet S, Noordam R, Blauw LL, Gast KB, Rensen PCN, et al. Mendelian randomization analysis of cholesteryl ester transfer protein and subclinical atherosclerosis: A population-based study. J Clin Lipidol. 2018;12(1):137-44.e1.
Dekker SA, Noordam R, Biermasz NR, de Roos A, Lamb HJ, Rosendaal FR, et al. Habitual Sleep Measures are Associated with Overall Body Fat, and not Specifically with Visceral Fat, in Men and Women. Obesity (Silver Spring). 2018;26(10):1651-8.
Eggink HM, Tambyrajah LL, van den Berg R, Mol IM, van den Heuvel JK, Koehorst M, et al. Chronic infusion of taurolithocholate into the brain increases fat oxidation in mice. J Endocrinol. 2018;236(2):85-97.
Held NM, Kuipers EN, van Weeghel M, van Klinken JB, Denis SW, Lombès M, et al. Pyruvate dehydrogenase complex plays a central role in brown adipocyte energy expenditure and fuel utilization during short-term beta-adrenergic activation. Sci Rep. 2018;8(1):9562.
Jonker JT, de Heer P, Engelse MA, van Rossenberg EH, Klessens CQF, Baelde HJ, et al. Metabolic imaging of fatty kidney in diabesity: validation and dietary intervention. Nephrol Dial Transplant. 2018;33(2):224-30.
Koorneef LL, van den Heuvel JK, Kroon J, Boon MR, t Hoen PAC, Hettne KM, et al. Selective Glucocorticoid Receptor Modulation Prevents and Reverses Nonalcoholic Fatty Liver Disease in Male Mice. Endocrinology. 2018;159(12):3925-36.
Kroon J, Koorneef LL, van den Heuvel JK, Verzijl CRC, van de Velde NM, Mol IM, et al. Selective Glucocorticoid Receptor Antagonist CORT125281 Activates Brown Adipose Tissue and Alters Lipid Distribution in Male Mice. Endocrinology. 2018;159(1):535-46.
Kuipers EN, Dam ADV, Held NM, Mol IM, Houtkooper RH, Rensen PCN, et al. Quercetin Lowers Plasma Triglycerides Accompanied by White Adipose Tissue Browning in Diet-Induced Obese Mice. Int J Mol Sci. 2018;19(6).
Kuipers EN, Kantae V, Maarse BCE, van den Berg SM, van Eenige R, Nahon KJ, et al
.
High Fat Diet Increases Circulating Endocannabinoids Accompanied by Increased Synthesis Enzymes in Adipose Tissue. Front Physiol. 2018;9:1913.
Kuipers EN, van Dam AD, Ballak DB, de Wit EA, Dinarello CA, Stienstra R, et al. IL-37 Expression Reduces Lean Body Mass in Mice by Reducing Food Intake. Int J Mol Sci. 2018;19(8).
Li Z, Yi CX, Katiraei S, Kooijman S, Zhou E, Chung CK, et al. Butyrate reduces appetite and activates brown adipose tissue via the gut-brain neural circuit. Gut. 2018;67(7):1269-79.
Li-Gao R, de Mutsert R, Rensen PCN, van Klinken JB, Prehn C, Adamski J, et al. Postprandial metabolite profiles associated with type 2 diabetes clearly stratify individuals with impaired fasting glucose. Metabolomics. 2018;14(1):13.
Martinez-Tellez B, Nahon KJ, Sanchez-Delgado G, Abreu-Vieira G, Llamas-Elvira JM, van Velden FHP, et al. The impact of using BARCIST 1.0 criteria on quantification of BAT volume and activity in three independent cohorts of adults. Sci Rep. 2018;8(1):8567.
Martinez-Tellez B, Xu H, Sanchez-Delgado G, Acosta FM, Rensen PCN, Llamas-Elvira JM, et al. Association of wrist and ambient temperature with cold-induced brown adipose tissue and skeletal muscle [(18)F]FDG uptake in young adults. Am J Physiol Regul Integr Comp Physiol. 2018;315(6):R1281-r8.
Nahon KJ, Doornink F, Straat ME, Botani K, Martinez-Tellez B, Abreu-Vieira G, et al. Effect of sitagliptin on energy metabolism and brown adipose tissue in overweight individuals with prediabetes: a randomised placebo-controlled trial. Diabetologia. 2018;61(11):2386-97.
Nahon KJ, Kantae V, den Haan R, Hanssen MJW, Harms AC, van der Stelt M, et al. Gene Expression of Endocannabinoid System Components in Skeletal Muscle and Adipose Tissue of South Asians and White Caucasians with Overweight. Obesity (Silver Spring). 2018;26(8):1332-7.
Rozendaal YJW, Wang Y, Paalvast Y, Tambyrajah LL, Li Z, Willems van Dijk K, et al. In vivo and in silico dynamics of the development of Metabolic Syndrome. PLoS Comput Biol. 2018;14(6):e1006145.
Ruiz JR, Martinez-Tellez B, Sanchez-Delgado G, Osuna-Prieto FJ, Rensen PCN, Boon MR. Role of Human Brown Fat in Obesity, Metabolism and Cardiovascular Disease: Strategies to Turn Up the Heat. Prog Cardiovasc Dis. 2018;61(2):232-45.
Schilperoort M, van Dam AD, Hoeke G, Shabalina IG, Okolo A, Hanyaloglu AC, et al. The GPR120 agonist TUG-891 promotes metabolic health by stimulating mitochondrial respiration in brown fat. EMBO Mol Med. 2018;10(3).
Spaanderman DCE, Nixon M, Buurstede JC, Sips HC, Schilperoort M, Kuipers EN, et al. Androgens modulate glucocorticoid receptor activity in adipose tissue and liver. J Endocrinol. 2018.
Tahapary DL, de Ruiter K, Kurniawan F, Djuardi Y, Wang Y, Nurdin SME, et al. Impact of rural-urban environment on metabolic profile and response to a 5-day high-fat diet. Sci Rep. 2018;8(1):8149.
van Dam AD, van Beek L, Pronk ACM, van den Berg SM, Van den Bossche J, de Winther MPJ, et al. IgG is elevated in obese white adipose tissue but does not induce glucose intolerance via Fcγ-receptor or complement. Int J Obes (Lond). 2018;42(2):260-9.
van den Berg R, Kooijman S, Noordam R, Ramkisoensing A, Abreu-Vieira G, Tambyrajah LL, et al. A Diurnal Rhythm in Brown Adipose Tissue Causes Rapid Clearance and Combustion of Plasma Lipids at Wakening. Cell Rep. 2018;22(13):3521-33.
van der Tuin SJL, Li Z, Berbée JFP, Verkouter I, Ringnalda LE, Neele AE, et al. Lipopolysaccharide Lowers Cholesteryl Ester Transfer Protein by Activating F4/80(+)Clec4f(+)Vsig4(+)Ly6C(-) Kupffer Cell Subsets. J Am Heart Assoc. 2018;7(6).
van Eenige R, van der Stelt M, Rensen PCN, Kooijman S. Regulation of Adipose Tissue Metabolism by the Endocannabinoid System. Trends Endocrinol Metab. 2018;29(5):326-37.
van Eyk HJ, van Schinkel LD, Kantae V, Dronkers CEA, Westenberg JJM, de Roos A, et al. Caloric restriction lowers endocannabinoid tonus and improves cardiac function in type 2 diabetes. Nutr Diabetes. 2018;8(1):6.
van Loon NM, Ottenhoff R, Kooijman S, Moeton M, Scheij S, Roscam Abbing RLP, et al. Inactivation of the E3 Ubiquitin Ligase IDOL Attenuates Diet-Induced Obesity and Metabolic Dysfunction in Mice. Arterioscler Thromb Vasc Biol. 2018;38(8):1785-95.
van Loon NM, Rensen PCN, Zelcer N. IDOL in metabolic, neurodegenerative and cardiovascular disease. Aging (Albany NY). 2018;10(11):3042-3.
Bartelt A, John C, Schaltenberg N, Berbée JFP, Worthmann A, Cherradi ML, et al. Thermogenic adipocytes promote HDL turnover and reverse cholesterol transport. Nat Commun. 2017;8:15010.
Berbée JFP, Mol IM, Milne GL, Pollock E, Hoeke G, Lütjohann D, et al. Deuterium-reinforced polyunsaturated fatty acids protect against atherosclerosis by lowering lipid peroxidation and hypercholesterolemia. Atherosclerosis. 2017;264:100-7.
Blauw LL, Aziz NA, Tannemaat MR, Blauw CA, de Craen AJ, Pijl H, et al. Diabetes incidence and glucose intolerance prevalence increase with higher outdoor temperature. BMJ Open Diabetes Res Care. 2017;5(1):e000317.
Blauw LL, Noordam R, Trompet S, Berbée JFP, Rosendaal FR, van Heemst D, et al. Genetic variation in the obesity gene FTO is not associated with decreased fat oxidation: the NEO study. Int J Obes (Lond). 2017;41(10):1594-600.
Boon MR, Bakker LEH, Prehn C, Adamski J, Vosselman MJ, Jazet IM, et al. LysoPC-acyl C16:0 is associated with brown adipose tissue activity in men. Metabolomics. 2017;13(5):48.
Bus P, Pierneef L, Bor R, Wolterbeek R, van Es LA, Rensen PC, et al. Apolipoprotein C-I plays a role in the pathogenesis of glomerulosclerosis. J Pathol. 2017;241(5):589-99.
Christen T, de Mutsert R, Gast KB, Rensen PCN, de Koning E, Rosendaal FR, et al. Association of fasting triglyceride concentration and postprandial triglyceride response with the carotid intima-media thickness in the middle aged: The Netherlands Epidemiology of Obesity study. J Clin Lipidol. 2017;11(2):377-85.e1.
Deng H, Kooijman S, van den Nieuwendijk AM, Ogasawara D, van der Wel T, van Dalen F, et al. Triazole Ureas Act as Diacylglycerol Lipase Inhibitors and Prevent Fasting-Induced Refeeding. J Med Chem. 2017;60(1):428-40.
Hoeke G, Khedoe P, van Diepen JA, Pike-Overzet K, van de Ven B, Vazirpanah N, et al. The Effects of Selective Hematopoietic Expression of Human IL-37 on Systemic Inflammation and Atherosclerosis in LDLr-Deficient Mice. Int J Mol Sci. 2017;18(8).
Hoeke G, Nahon KJ, Bakker LEH, Norkauer SSC, Dinnes DLM, Kockx M, et al. Short-term cooling increases serum triglycerides and small high-density lipoprotein levels in humans. J Clin Lipidol. 2017;11(4):920-8.e2.
Hoeke G, Wang Y, van Dam AD, Mol IM, Gart E, Klop HG, et al. Atorvastatin accelerates clearance of lipoprotein remnants generated by activated brown fat to further reduce hypercholesterolemia and atherosclerosis. Atherosclerosis. 2017;267:116-26.
Kantae V, Nahon KJ, Straat ME, Bakker LEH, Harms AC, van der Stelt M, et al. Endocannabinoid tone is higher in healthy lean South Asian than white Caucasian men. Sci Rep. 2017;7(1):7558.
Katiraei S, Hoving LR, van Beek L, Mohamedhoesein S, Carlotti F, van Diepen JA, et al. BMT decreases HFD-induced weight gain associated with decreased preadipocyte number and insulin secretion. PLoS One. 2017;12(4):e0175524.
Khedoe P, de Kleijn S, van Oeveren-Rietdijk AM, Plomp JJ, de Boer HC, van Pel M, et al. Acute and chronic effects of treatment with mesenchymal stromal cells on LPS-induced pulmonary inflammation, emphysema and atherosclerosis development. PLoS One. 2017;12(9):e0183741.
Martinez-Tellez B, Sanchez-Delgado G, Boon MR, Rensen PCN, Ruiz JR. Activation and quantification of human brown adipose tissue: Methodological considerations for between studies comparisons: Comment on: Hot heads & cool bodies: The conundrums of human BAT activity research. Eur J Intern Med. 2017;40:e19-e21.
Martinez-Tellez B, Sanchez-Delgado G, Garcia-Rivero Y, Alcantara JMA, Martinez-Avila WD, Muñoz-Hernandez MV, et al. A New Personalized Cooling Protocol to Activate Brown Adipose Tissue in Young Adults. Front Physiol. 2017;8:863.
Nahon KJ, Boon MR, Doornink F, Jazet IM, Rensen PCN, Abreu-Vieira G. Lower critical temperature and cold-induced thermogenesis of lean and overweight humans are inversely related to body mass and basal metabolic rate. J Therm Biol. 2017;69:238-48.
Paalvast Y, Gerding A, Wang Y, Bloks VW, van Dijk TH, Havinga R, et al. Male apoE*3-Leiden.CETP mice on high-fat high-cholesterol diet exhibit a biphasic dyslipidemic response, mimicking the changes in plasma lipids observed through life in men. Physiol Rep. 2017;5(19).
Paulin N, Döring Y, Kooijman S, Blanchet X, Viola JR, de Jong R, et al. Human Neutrophil Peptide 1 Limits Hypercholesterolemia-induced Atherosclerosis by Increasing Hepatic LDL Clearance. EBioMedicine. 2017;16:204-11.
van Dam AD, Boon MR, Berbée JFP, Rensen PCN, van Harmelen V. Targeting white, brown and perivascular adipose tissue in atherosclerosis development. Eur J Pharmacol. 2017;816:82-92.
van Dam AD, Hanssen MJW, van Eenige R, Quinten E, Sips HC, Hülsman CJM, et al. South Asian men have lower expression of IFN signalling genes in white adipose tissue and skeletal muscle compared with white men. Diabetologia. 2017;60(12):2525-8.
van den Berg R, Noordam R, Kooijman S, Jansen SWM, Akintola AA, Slagboom PE, et al. Familial longevity is characterized by high circadian rhythmicity of serum cholesterol in healthy elderly individuals. Aging Cell. 2017;16(2):237-43.
van den Berg SM, van Dam AD, Kusters PJH, Beckers L, den Toom M, van der Velden S, et al. Helminth antigens counteract a rapid high-fat diet-induced decrease in adipose tissue eosinophils. J Mol Endocrinol. 2017;59(3):245-55.
van den Berg SM, van Dam AD, Rensen PC, de Winther MP, Lutgens E. Immune Modulation of Brown(ing) Adipose Tissue in Obesity. Endocr Rev. 2017;38(1):46-68.
Bakker LE, Boon MR, Annema W, Dikkers A, van Eyk HJ, Verhoeven A, et al. HDL functionality in South Asians as compared to white Caucasians. Nutr Metab Cardiovasc Dis. 2016;26(8):697-705.
Blauw LL, de Mutsert R, Lamb HJ, de Roos A, Rosendaal FR, Jukema JW, et al. Serum CETP concentration is not associated with measures of body fat: The NEO study. Atherosclerosis. 2016;246:267-73.
Hoeke G, Kooijman S, Boon MR, Rensen PC, Berbée JF. Role of Brown Fat in Lipoprotein Metabolism and Atherosclerosis. Circ Res. 2016;118(1):173-82.
Khedoe PP, Rensen PC, Berbée JF, Hiemstra PS. Murine models of cardiovascular comorbidity in chronic obstructive pulmonary disease. Am J Physiol Lung Cell Mol Physiol. 2016;310(11):L1011-27.
Kockx M, Glaros E, Leung B, Ng TW, Berbée JF, Deswaerte V, et al. Low-Density Lipoprotein Receptor-Dependent and Low-Density Lipoprotein Receptor-Independent Mechanisms of Cyclosporin A-Induced Dyslipidemia. Arterioscler Thromb Vasc Biol. 2016;36(7):1338-49.
Laurila PP, Soronen J, Kooijman S, Forsström S, Boon MR, Surakka I, et al. USF1 deficiency activates brown adipose tissue and improves cardiometabolic health. Sci Transl Med. 2016;8(323):323ra13.
Louwe MC, Lammers B, Frias MA, Foks AC, de Leeuw LR, Hildebrand RB, et al. Abca1 deficiency protects the heart against myocardial infarction-induced injury. Atherosclerosis. 2016;251:159-63.
Marsch E, Demandt JA, Theelen TL, Tullemans BM, Wouters K, Boon MR, et al. Deficiency of the oxygen sensor prolyl hydroxylase 1 attenuates hypercholesterolaemia, atherosclerosis, and hyperglycaemia. Eur Heart J. 2016;37(39):2993-7.
Mook-Kanamori DO, de Mutsert R, Rensen PC, Prehn C, Adamski J, den Heijer M, et al. Type 2 diabetes is associated with postprandial amino acid measures. Arch Biochem Biophys. 2016;589:138-44.
Nahon KJ, Boon MR, Bakker LE, Prehn C, Adamski J, Jazet IM, et al. Physiological changes due to mild cooling in healthy lean males of white Caucasian and South Asian descent: A metabolomics study. Arch Biochem Biophys. 2016;589:152-7.
Schilperoort M, Hoeke G, Kooijman S, Rensen PC. Relevance of lipid metabolism for brown fat visualization and quantification. Curr Opin Lipidol. 2016;27(3):242-8.
van Dam AD, Bekkering S, Crasborn M, van Beek L, van den Berg SM, Vrieling F, et al. BCG lowers plasma cholesterol levels and delays atherosclerotic lesion progression in mice. Atherosclerosis. 2016;251:6-14.
van den Berg R, Mook-Kanamori DO, Donga E, van Dijk M, van Dijk JG, Lammers GJ, et al. A single night of sleep curtailment increases plasma acylcarnitines: Novel insights in the relationship between sleep and insulin resistance. Arch Biochem Biophys. 2016;589:145-51.
van den Heuvel JK, Boon MR, van Hengel I, Peschier-van der Put E, van Beek L, van Harmelen V, et al. Identification of a selective glucocorticoid receptor modulator that prevents both diet-induced obesity and inflammation. Br J Pharmacol. 2016;173(11):1793-804.
Berbée JF, Boon MR, Khedoe PP, Bartelt A, Schlein C, Worthmann A, et al. Brown fat activation reduces hypercholesterolaemia and protects from atherosclerosis development. Nat Commun. 2015;6:6356.
Blauw LL, Boon MR, Rosendaal FR, de Mutsert R, Gast KB, van Dijk KW, et al. Smoking is associated with increased resting energy expenditure in the general population: The NEO study. Metabolism. 2015;64(11):1548-55.
Boon MR, Bakker LE, Haks MC, Quinten E, Schaart G, Van Beek L, et al. Short-term high-fat diet increases macrophage markers in skeletal muscle accompanied by impaired insulin signalling in healthy male subjects. Clin Sci (Lond). 2015;128(2):143-51.
Boon MR, Bakker LE, van der Linden RA, van Ouwerkerk AF, de Goeje PL, Counotte J, et al. High prevalence of cardiovascular disease in South Asians: Central role for brown adipose tissue? Crit Rev Clin Lab Sci. 2015;52(3):150-7.
Coomans CP, Lucassen EA, Kooijman S, Fifel K, Deboer T, Rensen PC, et al. Plasticity of circadian clocks and consequences for metabolism. Diabetes Obes Metab. 2015;17 Suppl 1:65-75.
Dijk W, Heine M, Vergnes L, Boon MR, Schaart G, Hesselink MK, et al. ANGPTL4 mediates shuttling of lipid fuel to brown adipose tissue during sustained cold exposure. Elife. 2015;4.
Khedoe PP, Hoeke G, Kooijman S, Dijk W, Buijs JT, Kersten S, et al. Brown adipose tissue takes up plasma triglycerides mostly after lipolysis. J Lipid Res. 2015;56(1):51-9.
Kooijman S, de Jonge WJ, Rensen PC. Reply to "Letter to the editor: Parasympathetic innervation of the rodent spleen?". Am J Physiol Heart Circ Physiol. 2015;309(12):H2159.
Kooijman S, Meurs I, van Beek L, Khedoe PP, Giezekamp A, Pike-Overzet K, et al. Splenic autonomic denervation increases inflammatory status but does not aggravate atherosclerotic lesion development. Am J Physiol Heart Circ Physiol. 2015;309(4):H646-54.
Kooijman S, Meurs I, van der Stoep M, Habets KL, Lammers B, Berbée JF, et al. Hematopoietic α7 nicotinic acetylcholine receptor deficiency increases inflammation and platelet activation status, but does not aggravate atherosclerosis. J Thromb Haemost. 2015;13(1):126-35.
Kooijman S, van den Berg R, Ramkisoensing A, Boon MR, Kuipers EN, Loef M, et al. Prolonged daily light exposure increases body fat mass through attenuation of brown adipose tissue activity. Proc Natl Acad Sci U S A. 2015;112(21):6748-53.
Kooijman S, van den Heuvel JK, Rensen PCN. Neuronal Control of Brown Fat Activity. Trends Endocrinol Metab. 2015;26(11):657-68.
Kooijman S, Wang Y, Parlevliet ET, Boon MR, Edelschaap D, Snaterse G, et al. Central GLP-1 receptor signalling accelerates plasma clearance of triacylglycerol and glucose by activating brown adipose tissue in mice. Diabetologia. 2015;58(11):2637-46.
Kühnast S, van der Tuin SJ, van der Hoorn JW, van Klinken JB, Simic B, Pieterman E, et al. Anacetrapib reduces progression of atherosclerosis, mainly by reducing non-HDL-cholesterol, improves lesion stability and adds to the beneficial effects of atorvastatin. Eur Heart J. 2015;36(1):39-48.
van Beek L, van Klinken JB, Pronk AC, van Dam AD, Dirven E, Rensen PC, et al. The limited storage capacity of gonadal adipose tissue directs the development of metabolic disorders in male C57Bl/6J mice. Diabetologia. 2015;58(7):1601-9.
van Beek L, Vroegrijk IO, Katiraei S, Heemskerk MM, van Dam AD, Kooijman S, et al. FcRγ-chain deficiency reduces the development of diet-induced obesity. Obesity (Silver Spring). 2015;23(12):2435-44.
van Dam AD, Kooijman S, Schilperoort M, Rensen PC, Boon MR. Regulation of brown fat by AMP-activated protein kinase. Trends Mol Med. 2015;21(9):571-9.
van Dam AD, Nahon KJ, Kooijman S, van den Berg SM, Kanhai AA, Kikuchi T, et al. Salsalate activates brown adipose tissue in mice. Diabetes. 2015;64(5):1544-54.
van den Beukel JC, Boon MR, Steenbergen J, Rensen PC, Meijer OC, Themmen AP, et al. Cold Exposure Partially Corrects Disturbances in Lipid Metabolism in a Male Mouse Model of Glucocorticoid Excess. Endocrinology. 2015;156(11):4115-28.
van der Tuin SJ, Kühnast S, Berbée JF, Verschuren L, Pieterman EJ, Havekes LM, et al. Anacetrapib reduces (V)LDL cholesterol by inhibition of CETP activity and reduction of plasma PCSK9. J Lipid Res. 2015;56(11):2085-93.
Wang Y, van der Tuin S, Tjeerdema N, van Dam AD, Rensen SS, Hendrikx T, et al. Plasma cholesteryl ester transfer protein is predominantly derived from Kupffer cells. Hepatology. 2015;62(6):1710-22.